This review explores the molecular mechanisms underpinning HCM and the rapidly advancing field of HCM translational research, including gene therapy and small-molecule interventions targeting ...

which predominantly code for proteins present in the cardiac sarcomere. Other inherited forms of cardiomyopathies that can trigger HF are metabolic and mitochondrial cardiomyopathies that result from ...

Skeletal muscle is one of the tissues with the highest ability to regenerate, a finely controlled process which is critically depending on muscle stem cells. Muscle stem cell functionality depends on ...

Interestingly, faster bundling results in accelerated sarcomere assembly. Since tension can be transmitted ... Rutgers University), GFP-titin (derived from PGP-1, Sharma et al., 2018) and ...

This abrupt change to otherwise-normal sarcomeres allows us to precisely track the immediate changes in sarcomere structure and function with titin loss, and study as purely a titin-based effect as ...