School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, the University of Dublin, College Green, Dublin 2 D02 PN40, Ireland Trinity Translational Medicine Institute, Trinity College ...

The team, publishing in the journal Advanced Science, used a new drug discovery screening platform technology, called the Transcription Block Survival (TBS) assay, which tests a huge number of ...

In the literature, different results have been reported. By using the LIVE/DEAD assay, Machado et al. (26) verified cytotoxicity in HepG2 and HUVEC (human umbilical vein endothelial) cells treated ...

Molecular Cancer Therapeutics publishes articles on the discovery and preclinical development of novel therapeutic agents for oncology, preclinical studies of approved therapeutics, mechanisms of drug ...

General Steps and Considerations for High Throughput Screening Miniaturization, automation, and quick assay readouts are key technical considerations for setting up laboratory workflows for high ...

The most well-known model is the two-chamber migration assay, also known as the transwell assay (Falasca ... and does it express known markers for the BEC type of interest? Also, while HUVEC are ...

Force measurement on a spheroid poses two formidable problems. First, current 3D finite element force reconstruction methods that have been designed for single cells in a non-linear material such as ...

Angiogenesis requires the temporal coordination of the proliferation and the migration of endothelial cells. Here, we investigated the regulatory role of microRNAs (miRNAs) in harmonizing angiogenesis ...

This paper describes a 3D cytotoxicity assay using an injection molded plastic array culture (CACI-IMPACT) device for 3D cytotoxicity assay to assess killing abilities of cytotoxic lymphocytes in 3D ...