Within healthy and inflamed intestinal tissues, single-cell omics, particularly single-cell RNA sequencing, have contributed to uncovering novel cell types and cell functions linked to disease ...

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to ...

Q-rH, J-jM, and L-yZ prepared the nuclei sample and performed the single-nuclei RNA-seq. S-jQ, L-yZ, and R-yC performed functional validation. S-jQ, Q-rH, H-cL, and BL wrote the manuscript with input ...

memento is a Python package for estimating the mean, variability, and gene correlation from scRNA-seq data as well as contructing a framework for hypothesis testing of differences in these parameters ...

Methods Single-nucleus RNA sequencing of 82 924 nuclei from 21 IFPs (n=6 healthy control and n=15 KOA donors), spatial transcriptomics and bioinformatic analyses were used to identify contributions of ...

This organization has no public members. You must be a member to see who’s a part of this organization.

Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, P. R. China University of Chinese Academy of Sciences, Beijing 100049, P. R. China State Key ...

This manuscript from So et al. describes what is suggested to be an improved protocol for single-nuclei RNA sequencing (snRNA-seq) of adipose tissue. The authors provide evidence that modifications to ...

Here, we classified spinal cord neurons into 21 subclusters and determined their distribution from nine human donors using single-nucleus RNA sequencing and spatial transcriptomics. Moreover, we ...

However, its pathogenesis is complex and has not been fully elucidated yet. Over the past few years, single-cell RNA sequencing (scRNA-seq) has been developed and widely used in many biological fields ...