Proper spindle alignment is key for the correct implementation of the unequal fate of the stem-cell daughters. In both neuroblasts and mGSCs, the two centrosomes are unequal. One is a ...

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The spindle assembly checkpoint (SAC ... Because both Bub1 and BubR1 hetero-dimerize with Bub3, a targeting adaptor for phosphorylated kinetochores, the molecular basis for such sub-functionalization ...

An organised spindle is crucial to the fidelity of chromosome segregation, but the relationship between spindle structure and function is not well understood in any cell type. The anaphase B spindle ...