Mitochondrial DNA (mtDNA) quantification is crucial in understanding mitochondrial dysfunction, which is linked to a variety of diseases, including cancer and neurodegenerative disorders. Traditional ...

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions. By Gina Kolata Researchers have corrected a disease ...

A research team has identified NEAT1, a long non-coding RNA, as a key player in DNA repair. This discovery links RNA metabolism to genome stability and opens up potential new cancer treatments. Credit ...

The prosecution’s most important piece of evidence is a DNA sample taken from a knife sheath left at the crime scene. Investigators then used investigative genetic genealogy, or IGG, a forensic ...

Contact hotspots are enriched for nucleosome-encoded signals. De novo calling of DNA contacts between molecules is difficult to achieve with microscopy but can be done using capture of chromosome ...

I was one of the first to spit into a test tube, giving up my DNA forever to learn more about my health and heredity. You know, the ones that promise to connect you with distant relatives you didn ...

Here, we discuss how the torsional stress of the DNA helix acts as a buffer, regulating both chromatin compaction and accessibility. We will focus on chromatin supercoiling and on the emerging role of ...

Alternatively, introduction of naked nucleic acids, including supercoiled DNA, messenger RNA (mRNA), small interfering RNA (siRNA), and guide RNA (gRNA), can be achieved by non-viral transfection.

DNA binding is potentiated by dephosphorylation and is not ... φX174 Virion (circular ssDNA), φX174 Virion cut with HaeIII (15 fragments of ssDNA), pSP73JY10 (supercoiled dsDNA, Yeeles et al., 2011), ...