Previous studies have identified the tricarboxylic acid (TCA) cycle, a key part of cellular metabolism, as a metabolic driver ...

In localized non-small cell lung cancer (NSCLC), a tumor's ability to use carbon from glucose to feed the tricarboxylic acid (TCA) cycle predicts cancer spread beyond the lung, months to years ...

Northwestern Medicine investigators have uncovered new insights into how metabolic dysfunction contributes to Parkinson's disease, according to a study published in Nature Communications.

Such was the case for Hans Krebs, the biochemist who nabbed the award in 1953 for discovering the citric acid cycle, or “Krebs cycle”—the cellular pathway that converts carbohydrates, fats, and ...

TCA cycle enzyme activities and mitochondrial respiration rates remained unchanged, indicating that metabolic disruption was not the primary defect. In the liver, triple knockouts (Alb-Drp1flox ...

and FADH 2 (reduced flavin adenine dinucleotide), that are produced by the oxidation of carbohydrates (the tricarboxylic acid (TCA) cycle) and fatty acids is coupled to the generation of an ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.