In addition to the pathways explored in this work, numerous previous studies have shown that TGF-β1 induces myofibroblast differentiation including collagen and α-SMA expression via Smad-mediated ...

In the present study, we demonstrate that sGC stimulation interferes with transforming growth factor β (TGFβ ... inhibits SMAD-independent TGFβ signalling and reduces fibroblast activation and ...

Inhibition of CK2 by TBB abrogated the TGFβ-induced activation of JAK2/STAT3 signalling and prevented the stimulatory effects of TGFβ on collagen release and ... orally active ATP-competitive ...

10 Detection of RhoA-GTP, S1P, total soluble collagen, and supernatant TGF-β1 Analysis ... 11 Primary antibodies against SPHK1, TGF-β1, α-SMA, vimentin, E-cadherin and p-Smad were used. See online ...

Neuraminidase (NA) of IAV is able to activate latent TGF-β and the downstream TGF-β signaling pathway ... and 5-μm sections were stained with Masson’s trichrome reagent to demonstrate collagen. The ...

There are two important regulators of collagen production: transforming growth factor (TGF)-b and activator protein (AP)-1. TGF-b is a cytokine that promotes collagen production (MassaguE9 ...

Our bodies naturally produce a protein known as collagen, which is found in our skin, bones, and connective tissues. However, as we age, the production of collagen by our bodies drops, leading to ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

Primers specific for porcine TGF-β1 in pPK9a were used for distinguishing ... was assessed by using three independent methods: the collagen quantitation by measuring hydroxyproline content ...