Nonetheless, both tags enable accurate quantitative analysis of HEK293 cell proteomes. DiAla and DiLeu tags are then applied to study the TGF-β/Smad3 pathway with four differentially treated mouse ...

Award-winning research presented by Hangjie Fu at EHA shows that ellagic acid can protect against iron overload-induced liver ...

the TGF-β signaling pathway and miRNAs have played important roles in the pathogenesis of PH. TGF-β regulates the proliferation, migration and fibrosis of vascular smooth muscle cells through the ...

The study is solid and further in vivo evidence on how target factors participate in the occurrence of placental structural disorders and diseases through potential downstream pathways will be ...

This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Longhua, Haikou 570102, P. R. China Hainan Province Clinical Medical Center of Respiratory Disease, ...

Increased TGF-β1 promotes the phosphorylation and nuclear translocation of Smad2/3, sequentially activating the transcription of Sp1, which is regarded as a key feature of AngII-induced synaptic and ...

TGF- ß activates a number of Smad-dependent and independent signalling pathways, including BMP, CSF-1, RANKL/RANK, TRAF6, NF-kB, AP-1, Notch, Ras/MAPK, PI 3-K/Akt, p38, JNK, and Rho A/ROCK. Activation ...