These discoveries have led to novel therapies for diseases associated with fibrosis, diabetes, and cancer by rebalancing TGF-β/Smad signalling ... explosion of this ‘western’ disease in ...

The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell ...