Prominent among these regulatory signals is the transforming growth factor-β (TGF-β) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup ...

Head and neck cancers are among the most difficult to treat. They can be aggressive and are located near some of the body's ...

New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies.

In patients with systemic sclerosis, impaired activity of transforming growth factor β (TGF-β) has a central role in the pathogenesis of fibrosis, which leads to the progression of the disease ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Autoimmune diseases, such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA), affect millions of people ...

Dr. Jin Wang from University of Chinese Academy of Sciences/ State University of New York at Stony Brook and Dr. Xiaona Fang ...

Bicara presented Phase I/Ib data for its ficerafusp alfa, a bispecific fusion protein targeting EGFR and transforming growth ...

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

Research reveals why EGFR-targeted cancer therapies often face resistance, leading to ongoing studies on combination treatments.

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

Anita Turk, MD, discusses the unmet needs that still exist in the realm of colorectal cancer treatment and management.