SOUTH SAN FRANCISCO, Calif., June 27, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced that following the review of data from the recently terminated BEACON-IPF Phase ...

We identified a rhodol bearing a hydroxymethyl group (HMDER) as a suitable scaffold for designing fluorescence probes for various hydrolases. HMDER shows strong fluorescence at physiological pH, but ...

In addition, TGF-β can inhibit the growth and survival of many transformed lymphocyte progenitors, including a subset of chronic lymphocytic leukemia and acute lymphoblastic leukemia cells, which ...

This article explores the complex roles of cytokine networks in the development and progression of autoimmune diseases.

We’ve long blamed osteoarthritis on “wear and tear,” the price of a life well-lived. But could the cause be a more ancient ...

Objective Tumour-associated macrophages (TAMs) and their alternative activation contribute greatly to the development of hepatocellular carcinoma (HCC). Tim-3 is highly expressed on macrophages and ...

TGF-β pathway critically regulates cellular mechanisms related to growth, differentiation, apoptosis, adhesion and motility 21. According to Shukla and Yuspa 5, the regulation of CLIC4 expression by ...

Exosomes: Tiny vesicles from stem cells that carry regenerative signals. They may be more potent than PRP, but they remain ...

TGF-β induces fibronectin expression in WB cells. In order to investigate the role of TGF-β in the fibrogenic process in hepatic stem cells, we first detected the expression of FN, an extracellular ...

For example, the DNA methylation status of TGF-β-related genes such as TGFBR2 and Smad2/3 may affect their expression and thus TGF-β signaling. Studies have shown that hypermethylation or ...

Thioglycosides are prominent glycosides in biology and drug discovery because of their unique physicochemical and biological properties. The stereoselective construction of thioglycosides from ...