He suggested that the net outcome of TGF-β signals is determined by a cell specific complex network of cross-talking signals. The combined DNA-binding specificity of a SMAD-cofactor complex dictates ...

Conclusions We characterise VDR as a negative regulator of TGF-β/Smad signalling. Impaired VDR signalling with reduced expression of VDR and decreased levels of its ligand may thus contribute to ...

The TGF-β/Smad signaling pathway is the major pathogenic mechanism in the development of CKD (Lan, 2011). Genetic knockout of Smad3 alleviated fibrosis in several animal models of CKD, indicating that ...

This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...

Embraer, Nvidia and TSMC share key strengths, such as a wide competitive moat and huge market ... [+] demand, positioning them for significant future growth. Investing in high-growth companies ...

The high mobility group A (HMGA) family is composed of four proteins, HMGA1a, HMGA1b, HMGA1c and HMGA2, encoded by two distinct genes. HMGA1 proteins are products of the same gene, generated ...

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The maritime industry, a cornerstone of global trade, is undergoing a significant transformation through the adoption of digitalization and smart shipping technologies. As the industry navigates ...

Smadav Pro Key is an impressive antivirus software. The Smadav 2025 key can provide extra protection for your computer, and the USB memory stick can completely protect and completely eliminate various ...

This Agenda is a plan of action for people, planet and prosperity. It also seeks to strengthen universal peace in larger freedom, We recognize that eradicating poverty in all its forms and dimensions, ...