He suggested that the net outcome of TGF-β signals is determined by a cell specific complex network of cross-talking signals. The combined DNA-binding specificity of a SMAD-cofactor complex dictates ...

Conclusions We characterise VDR as a negative regulator of TGF-β/Smad signalling. Impaired VDR signalling with reduced expression of VDR and decreased levels of its ligand may thus contribute to ...

The TGF-β/Smad signaling pathway is the major pathogenic mechanism in the development of CKD (Lan, 2011). Genetic knockout of Smad3 alleviated fibrosis in several animal models of CKD, indicating that ...

This important work provides another layer of regulatory mechanism for TGF-beta signaling activity ... We show that the oncoprotein Rudhira/BCAS3 facilitates Smad-MT dissociation upon ligand-mediated ...

Among these factors, the transforming growth factor (TGF)-β family is important in both lineage selection and progression of differentiation of most, if not all, cell and tissue types.

This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...

Berlin brought down its 2025 economic growth forecast from 1.1% to 0.3%. A government report cited the collapse of the government as the main reason. https://p.dw.com ...

Embraer, Nvidia and TSMC share key strengths, such as a wide competitive moat and huge market ... [+] demand, positioning them for significant future growth. Investing in high-growth companies ...

The race to redefine customer experience (CX) is accelerating. As interactions between businesses, brands and their customers shift, I believe we will see significant developments across the ...

AC Future hasn't broken down all the dimensions, but it has stated that the AI-THd has the same 400 square feet (37 sq m) of floor area when expanded as the original eTH concept advertised. Also ...

LONDON, Jan 29 (Reuters) - Diageo's new finance chief Nik Jhangiani is under pressure to row back on the spirits giant's medium-term sales goals next week, which some investors say may no longer ...