Her data argued that CML cells are dependent on BCR-ABL even at relapse. In theory, one could screen for drugs that inhibit imatinib-resistant BCR-ABL mutants, and these drugs should be effective ...

We previously introduced the concept of 'oncogene addiction' to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or 'addicted' to ...

Here we focus on the transformation assay, which scientists first used to identify oncogenes and tumor suppressors and study their affect on cell cycle progression. Even more important will be ...