But complete proteome characterization has been hindered by the dynamic range and detection sensitivity of experimental designs, which are not adequate to the very wide range of protein abundances.

Scientists have long struggled to target proteins that lack defined structure and are involved in cancer, neurodegenerative disorders like Parkinson's disease, and other serious illnesses. Now, a new ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

Advances in proteomics are now empowering researchers to analyze thousands of proteins simultaneously. With the latest high-throughput approach, scientists can measure proteins rapidly, broadly, and ...

(1) The lock-and-key model of protein interactions has dominated biology for more than a century, shaping how scientists study molecular communication and approach the development of novel ...

Even as it passes its 40 th birthday 1, polyacrylamide gel electrophoresis (PAGE) remains one of the most potent tools for protein analysis. Nonetheless, researchers conducting broader experiments ...

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, United States ...

The proteome refers to the complete set of proteins expressed in a cell, tissue or organism at any given time. Proteins are often nicknamed “cellular workhorses” due to their involvement in a wide ...

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