A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight ...

The three-carbon pyruvic acid molecules are converted to a two-carbon molecule attached to Coenzyme A, called acetyl CoA, via the process of pyruvate oxidation. It is the product, acetyl CoA ...

The citric acid cycle begins with the reaction that combines the two-carbon acetyl CoA with a four-carbon oxaloacetic acid to produce the six-carbon molecule citrate. Acetyl-CoA is regulated by ...

ALCAR is a naturally occurring substance. It can be metabolized to acetyl-COA by the carnitine transferase reaction and may serve as an alternative source of fuel for the citric-acid cycle, thus ...

Brain tumor growth depends on converting an energy source for the brain known as acetate, to acetyl-CoA — a molecule involved in biochemical ... is in pursuit of another for newer compounds and is ...