Novak Djokovic was beaten 7-6 (6), 6-3 by big-serving Reilly Opelka in the Brisbane International quarterfinals.

Djokovic is in search of his 25th Grand Slam title at the Australian Open, but fell short of the semifinals at his warm-up event.

Novak Djokovic suffered a massive upset at the Brisbane International on Friday. Competing in his first tournament since October, Djokovic was dumped out in the quarter-final. Reilly Opelka, whose ranking has dropped to No. 293 following a two-year injury layoff, caused all sorts of problems for the Serb, winning 7-6 (6) 6-3.