Feb 8, 2021 · We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-enriched...

Oct 18, 2022 · Using the Chromium Single Cell 3’ Gene Expression assay, researchers performed snRNA-seq on dlPFC tissue from humans and three other primates (chimpanzees, rhesus macaques, and common marmosets) and characterized 114 distinct subtypes of cells.

Human M1 10x This data set includes single-nucleus transcriptomes from 76,533 total nuclei derived from 2 post-mortem human brain specimens, to survey cell type diversity in the primary motor cortex ( M1C or M1).

We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-enriched expression signatures and refined associations to previous laminar markers.

Apr 14, 2020 · Leveraging spatial gene expression technology, the research team analyzed 12 tissue samples from the six-layered human dorsolateral prefrontal cortex, and explored how the laminar position of a brain cell impacts its gene expression, morphology, physiology, and function.

Oct 12, 2023 · We simultaneously profiled gene expression and chromatin accessibility in 45,549 cortical nuclei across six broad developmental time points from fetus to adult. We identified cell type–specific domains in which chromatin accessibility is highly correlated with gene expression.

We sought to create a data-driven molecular neuroanatomical map of the human dorsolateral prefrontal cortex (DLPFC) at cellular resolution using unsupervised transcriptomic approaches to identify spatial domains associated with neuropsychiatric and neurodevelopmental disorders.

Combine whole transcriptome spatial analysis with high-plex protein detection using NGS in the same tissue section. Gain a deeper, more holistic understanding of tissue organization, using Visium CytAssist to expand sample access and ease workflows.

This study includes all human data and includes a single preparation taken through nuclei isolation and indexed tagmentation using 96 indexes then split to produce two datasets, one targeting 20k cells and one targeting 70k, each using a …

We simultaneously profiled gene expression and chromatin accessibility in 45,549 individual nuclei isolated from the human cortex across 6 broad developmental time-points from fetus to adult.