Marlise I Klein. 2 Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America. Find articles by Marlise I Klein. ... Koo H, Schobel B, Scott-Anne K, Watson G, Bowen WH, et al. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res. 2005;84:1016 ...

The assembly of cariogenic biofilms is a prime example of how pathogenic bacteria such as Streptococcus mutans orchestrate the development of virulent biofilms on (tooth) surfaces, as an extracellular matrix assembles (as reviewed in Hamada and Slade, 1980; Loesche, 1986; Bowen and Koo, 2011).

Aug 23, 2013 · Feng Guoping, Klein Marlise I, Gregoire Stacy, Singh Ajay P, Vorsa Nicholi, Koo Hyun: The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms. Biofouling 29(6): 629-40, 2013.

Apr 5, 2012 · Data reveal that the production of the EPS-matrix helps to create spatial heterogeneities by forming an intricate network of exopolysaccharide-enmeshed bacterial-islets (microcolonies) through localized cell-to-matrix interactions.

Oct 19, 2010 · We conducted a comprehensive study to further investigate the influence of the dietary carbohydrates on S. mutanstranscriptome at distinct stages of biofilm development using whole genomic profiling with a new computational tool (MDV) for data mining.

In this study, we used a high-throughput quantitative proteomics approach to examine how S. mutans produces relevant proteins that facilitate its establishment and optimal survival during mixed-species biofilms development induced by sucrose.

Jan 31, 2011 · We found that the saliva pH is severely decreased in a mouse model of cystic fibrosis disease (CF). Given the close relationship between pH and caries development, we hypothesized that caries incidence might be elevated in the mouse CF model.

EPS produced by S. mutans-derived exoenzymes promote local accumulation of microbes on the teeth, while forming a spatially heterogeneous and diffusion-limiting matrix that protects embedded bacteria.

Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA …